Pervasive and programmed nucleosome distortion on single chromatin fibres

SAMOSA from E14 mouse ES cells We compiled a large compendium of SAMOSA data from wild-type E14 mouse ES cells, comprising both newly generated datasets and published datasets from our laboratory, including: (1) our study on the function of ISWI-family remodelling complexes 3 ; (2) samples prepared with our SMRT-Tag protocol, which uses a transposase-based strategy for PacBio library preparation from lower input amounts of footprinted DNA 38 ; and (3) mouse ES cells labelled with the …