The past, present and future of de novo protein design

Nature News ·

The past, present and future of de novo protein design

Pan, X. & Kortemme, T. Recent advances in de novo protein design: principles, methods, and applications. J. Biol. Chem. 296 , 100558 (2021). …

Pan, X. & Kortemme, T. Recent advances in de novo protein design: principles, methods, and applications. J. Biol. Chem. 296 , 100558 (2021). Article CAS PubMed PubMed Central Google Scholar Woolfson, D. N. A brief history of de novo protein design: minimal, rational, and computational. J. Mol. Biol. 433 , 167160 (2021). Article CAS PubMed Google Scholar Marchand, A., Van Hall-Beauvais, A. K. & Correia, B. E. Computational design of novel protein-protein interactions—an overview on methodological approaches and applications. Curr. Opin. Struct. Biol. 74 , 102370 (2022). Article CAS PubMed Google Scholar Korendovych, I. V. & DeGrado, W. F. De novo protein design, a retrospective. Q. Rev. Biophys. 53 , e3 (2020). Article CAS PubMed PubMed Central Google Scholar Khakzad, H. et al. A new age in protein design empowered by deep learning. Cell Syst. 14 , 925–939 (2023). Article CAS PubMed Google Scholar Arnold, F. H. Directed evolution: bringing new chemistry to life. Angew. Chem. Int. Ed. 57 , 4143–4148 (2018). Article CAS Google Scholar Zhu, J. et al. Protein assembly by design. Chem. Rev. 121 , 13701–13796 (2021). Article CAS PubMed PubMed Central Google Scholar Anfinsen, C. B. Principles that govern the folding of protein chains. Science 181 , 223–230 (1973). Demonstration that a protein’s amino-acid sequence intrinsically encodes its native three-dimensional structure, establishing the foundational principle for all modern protein folding and design research . …

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