Quadruple pegRNA enables programmable and efficient large genomic insertion
Nature News ·

Anzalone, A. V. et al. Search-and-replace genome editing without double-strand breaks or donor DNA. Nature 576 , 149–157 (2019). Article CAS PubMed PubMed Central ADS Google Scholar Anzalone, A. V. …
Anzalone, A. V. et al. Search-and-replace genome editing without double-strand breaks or donor DNA. Nature 576 , 149–157 (2019). Article CAS PubMed PubMed Central ADS Google Scholar Anzalone, A. V. et al. Programmable deletion, replacement, integration and inversion of large DNA sequences with twin prime editing. Nat. Biotechnol. 40 , 731–740 (2022). Article CAS PubMed Google Scholar Wang, J. et al. Efficient targeted insertion of large DNA fragments without DNA donors. Nat. …
Original source: Nature News