Steatosis shapes prognosis-defining liver metastasis heterogeneity in CRC

Kow, A. W. C. Hepatic metastasis from colorectal cancer. J. Gastrointest. Oncol. 10 , 1274–1298 (2019). Article PubMed PubMed Central Google Scholar Morgan, E. et al. Global burden of colorectal cancer in 2020 and 2040: incidence and mortality estimates from GLOBOCAN. Gut 72 , 338–344 (2023). Article PubMed Google Scholar Siegel, R. L., Wagle, N. S. & Jemal, A. Leading cancer deaths in people younger than 50 years. JAMA 335 , 632–634 (2026). Article PubMed PubMed Central Google Scholar Nielsen, K., Rolff, H. C., Eefsen, R. L. & Vainer, B. The morphological growth patterns of colorectal liver metastases are prognostic for overall survival. Mod. Pathol. 27 , 1641–1648 (2014). Article CAS PubMed Google Scholar Höppener, D. J. et al. Histopathological growth patterns and survival after resection of colorectal liver metastasis: an external validation study. JNCI Cancer Spectr. 5 , pkab026 (2021). Article PubMed PubMed Central Google Scholar Vermeulen, P. B. et al. Liver metastases from colorectal adenocarcinomas grow in three patterns with different angiogenesis and desmoplasia. J. Pathol. 195 , 336–342 (2001). Article CAS PubMed Google Scholar Latacz, E. et al. Histopathological growth patterns of liver metastasis: updated consensus guidelines for pattern scoring, perspectives and recent mechanistic insights. Br. J. Cancer 127 , 988–1013 (2022). Article PubMed PubMed Central Google Scholar Höppener, D. J. et al. …