A <i>Streptomyces</i> megacluster encodes synergistic biotin-targeting antibiotics

Wiebach, V. et al. The anti-staphylococcal lipolanthines are ribosomally synthesized lipopeptides. Nat. Chem. Biol. 14 , 652–654 (2018). Article CAS PubMed Google Scholar Kayrouz, C. M., Zhang, Y., Pham, T. M. & Ju, K. S. Genome mining reveals the phosphonoalamide natural products and a new route in phosphonic acid biosynthesis. ACS Chem. Biol. 15 , 1921–1929 (2020). Article CAS PubMed Google Scholar Tang, X. et al. Identification of thiotetronic acid antibiotic biosynthetic pathways by target-directed genome mining. ACS Chem. Biol. 10 , 2841–2849 (2015). Article CAS PubMed PubMed Central Google Scholar Culp, E. J. et al. Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling. Nature 578 , 582–587 (2020). Article ADS CAS PubMed Google Scholar Culp, E. J. et al. ClpP inhibitors are produced by a widespread family of bacterial gene clusters. Nat. Microbiol. 7 , 451–462 (2022). Article CAS PubMed Google Scholar Li, C. et al. Discovery of unusual dimeric piperazyl cyclopeptides encoded by a Lentzea flaviverrucosa DSM 44664 biosynthetic supercluster. Proc. Natl Acad. Sci. USA 119 , e2117941119 (2022). Article CAS PubMed PubMed Central Google Scholar Morshed, M. T. et al. Chlorinated metabolites from Streptomyces sp. highlight the role of biosynthetic mosaics and superclusters in the evolution of chemical diversity. Org. Biomol. Chem. 19 , 6147–6159 (2021). Article CAS PubMed Google Scholar Meyer, K. J. & Nodwell, J. R. …