Alternate RNA decoding results in stable and abundant proteins in mammals

Cantwell-Dorris, E. R., O’Leary, J. J. & Sheils, O. M. BRAF V600E : implications for carcinogenesis and molecular therapy. Mol. Cancer Ther. 10 , 385–394 (2011). Article CAS PubMed Google Scholar Hart, J. R. et al. The butterfly effect in cancer: a single base mutation can remodel the cell. Proc. Natl Acad. Sci. USA 112 , 1131–1136 (2015). Article ADS CAS PubMed PubMed Central Google Scholar Wright, A. & Vissel, B. The essential role of AMPA receptor GluR2 subunit RNA editing in the normal and diseased brain. Front. Mol. Neurosci. 5 , 34 (2012). Article CAS PubMed PubMed Central Google Scholar Parker, J. & Friesen, J. D. “Two out of three” codon reading leading to mistranslation in vivo. Mol. Gen. Genet. 177 , 439–445 (1980). Article CAS PubMed Google Scholar Savitski, M. M., Nielsen, M. L. & Zubarev, R. A. ModifiComb, a new proteomic tool for mapping substoichiometric post-translational modifications, finding novel types of modifications, and fingerprinting complex protein mixtures. Mol. Cell. Proteomics 5 , 935–948 (2006). Article CAS PubMed Google Scholar Cox, J. & Mann, M. MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. Nat. Biotechnol. 26 , 1367–1372 (2008). Article CAS PubMed Google Scholar Wilhelm, M. et al. Deep learning boosts sensitivity of mass spectrometry-based immunopeptidomics. Nat. Commun. 12 , 3346 (2021). …