A first-in-class pulsatile FXR agonist for bile-acid-related liver diseases

Nature News ·

A first-in-class pulsatile FXR agonist for bile-acid-related liver diseases

Evans, R. M. & Mangelsdorf, D. J. Nuclear receptors, RXR, and the Big Bang. Cell 157 , 255–266 (2014). Article ADS CAS PubMed PubMed Central Google Scholar Parks, D. J. et al. …

Evans, R. M. & Mangelsdorf, D. J. Nuclear receptors, RXR, and the Big Bang. Cell 157 , 255–266 (2014). Article ADS CAS PubMed PubMed Central Google Scholar Parks, D. J. et al. Bile acids: natural ligands for an orphan nuclear receptor. Science 284 , 1365–1368 (1999). Article ADS CAS PubMed Google Scholar Schalm, S. W. et al. Diurnal serum levels of primary conjugated bile acids. Assessment by specific radioimmunoassays for conjugates of cholic and chenodeoxycholic acid. …

Original source: Nature News