Molecular glue degraders of HuR suppress BRAF-mutant colorectal cancer

Nature News ·

Molecular glue degraders of HuR suppress BRAF-mutant colorectal cancer

Corcoran, R. B. et al. EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal cancers to RAF inhibition with vemurafenib. Nature 2 , 227–235 (2012). …

Corcoran, R. B. et al. EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal cancers to RAF inhibition with vemurafenib. Nature 2 , 227–235 (2012). CAS Google Scholar Prahallad, A. et al. Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR. Nature 483 , 100–103 (2012). Article ADS CAS PubMed Google Scholar Kopetz, S. et al. …

Original source: Nature News