Substrate selectivity of the human RNA m<sup>5</sup>C methyltransferase NSUN2
Nature News ·

Roundtree, I. A., Evans, M. E., Pan, T. & He, C. Dynamic RNA modifications in gene expression regulation. Cell 169 , 1187–1200 (2017). Article CAS PubMed PubMed Central Google Scholar Suzuki, T. …
Roundtree, I. A., Evans, M. E., Pan, T. & He, C. Dynamic RNA modifications in gene expression regulation. Cell 169 , 1187–1200 (2017). Article CAS PubMed PubMed Central Google Scholar Suzuki, T. The expanding world of tRNA modifications and their disease relevance. Nat. Rev. Mol. Cell Biol. 22 , 375–392 (2021). Article CAS PubMed Google Scholar Delaunay, S., Helm, M. & Frye, M. RNA modifications in physiology and disease: towards clinical applications. Nat. Rev. Genet. 25 , 104–122 (2024). Article CAS PubMed Google Scholar Sun, H., Li, K., Liu, C. & Yi, C. Regulation and functions of non-m 6 A mRNA modifications. Nat. Rev. Mol. Cell Biol. 24 , 714–731 (2023). Article CAS PubMed Google Scholar Bohnsack, K. E., Höbartner, C. & Bohnsack, M. T. Eukaryotic 5-methylcytosine (m 5 C) RNA methyltransferases: mechanisms, cellular functions, and links to disease. Genes 10 , 102 (2019). Article CAS PubMed PubMed Central Google Scholar Yang, X. et al. 5-methylcytosine promotes mRNA export — NSUN2 as the methyltransferase and ALYREF as an m5C reader. Cell Res. 27 , 606–625 (2017). Article CAS PubMed PubMed Central Google Scholar Liu, F. et al. RNA m 5 C methylation mediated by Ybx1 ensures hematopoietic stem and progenitor cell expansion. Cell Rep. 44 , 115324 (2025). Article CAS PubMed Google Scholar Ma, H. L. et al. SRSF2 plays an unexpected role as reader of m 5 C on mRNA, linking epitranscriptomics to cancer. Mol. Cell 83 , 4239–4254.e10 (2023). …
Original source: Nature News