There is no vaccine for deadly hantavirus: what that means for future outbreaks

Medical staff arrive to evacuate passengers from MV Hondius , the cruise ship stricken by an outbreak of hantavirus. Credit: AFP via An outbreak of hantavirus onboard the cruise ship MV Hondius has thrown a spotlight on the rare but deadly infection and the lack of options for treatment and prevention. Three people who were on the ship have tested positive for the virus, including one passenger who died. Among another five people with suspected infections, two have died. Hantavirus typically spreads through the air, in particles from rodent urine, droppings or saliva. But some strains can occasionally spread between people who are in close contact. One of these strains, called Andes virus, is responsible for an ongoing outbreak in Argentina, and World Health Organization director-general Tedros Adhanom Ghebreyesus has confirmed that the passengers were infected with this strain, for which there are no specific treatments or vaccines. Scientists suspect that some of the travellers might have been infected in Argentina before boarding the cruise. Although hantavirus infections are rare, some strains have a fatality rate of up to 50%. For more than three decades, Jay Hooper, a virologist at the US Army Medical Research Institute of Infectious Diseases in Frederick, Maryland, has been working to develop a vaccine against several strains of hantavirus that can infect people, including the Andes virus. He talks to Nature about why these vaccines remain elusive. …