Two decades of PARP inhibitor synthetic lethality in cancer

Farmer, H. et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 434 , 917–921 (2005). ADS CAS PubMed Google Scholar Bryant, H. E. et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature 434 , 913–917 (2005). Together with Farmer et al. (2005), this study describes the discovery of the BRCA1/2 versus PARPi synthetic lethal effects. ADS CAS PubMed Google Scholar Weinstein, I. B. Cancer. …