A brain reward circuit inhibited by next-generation weight-loss drugs in mice

Mouse lines All experiments were conducted in compliance with the Association for Assessment of Laboratory Animal Care policies and approved by the Institutional Animal Care and Use Committees of the University of Virginia, University of Washington and University of California, Irvine. Mice were housed on a 12-h:12-h light–dark (LD) cycle with food (PicoLab Rodent Diet 5053) and water provided ad libitum unless otherwise indicated. …